AECOPD are a frequent cause of admission to hospital and even intensive care unit, and mainly responsible for the mortality associated with the disease.

The disease progression of COPD is variable, with some patients having a relatively stable course, while others suffer relentless progression leading to severe breathlessness, frequent acute exacerbation of COPD (AECOPD). Unfortunately, to date, there is no curative therapy for COPD, and these therapies are mostly palliative. Ĭhronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by chronically poor airflow, which now has been a global disease with an estimated 63 million people worldwide.

Trial registration: Name of the registry: U.S National Library of Medicine Clinical Trials Trial registration number: NCT04000451 Date of registration: June 27, 2019-Retrospectively registered URL of trial registry record. The trial demonstrated that hydrogen/oxygen therapy is superior to oxygen therapy in patient with AECOPD with acceptable safety and tolerability profile. No death and equipment defects were reported during study period. AEs were reported in 34 (63.0%) patients in Hydrogen/oxygen group and 42 (77.8%) in Oxygen group. Changes in pulmonary function, arterial blood gas and noninvasive oxygen saturation did not differ significantly between groups as well as other endpoints. There was a significant reduction of Cough Assessment Test score in Hydrogen/oxygen group compared to control (− 11.00 vs. Similar results were observed in other time points from day 2 through day 6. − 2.4 point difference: − 2.75, meeting criteria for superiority). ResultsĬhange of BCSS score in Hydrogen/oxygen group was larger than that in Oxygen group (− 5.3 vs. Adverse events (AEs) were recorded to evaluate safety. Primary endpoint was the change from baseline in BCSS score at day 7. Eligible patients were randomly assigned (in a 1:1 ratio) to receive either hydrogen/oxygen mixture or oxygen therapy. This prospective, randomized, double-blind, controlled clinical trial in 10 centres enrolled patient with AECOPD and a Breathlessness, Cough, and Sputum Scale (BCSS) score of at least 6 points. To investigate whether the administration of hydrogen/oxygen mixture was superior to oxygen in improving symptoms in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).

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